Fig. 7.

TeSLA for telomere detections in mTERT knockout mice and lung fibroblasts from a bowhead whale. a DNA extracted from mTERT ^+/− and mTERT ^−/− (4th generation, G4) mouse liver tissues were used to perform TeSLA (30 pg for each TeSLA reaction). Detected telomeres of three individual genomic DNA preps from the same mTERT ^−/− G4 mouse (91, 87, and 100 bands) are considerably more than telomeres that were detected from mTERT ^+/− liver tissue (36 bands). b TeSLA results of high-quality DNA extracted from early (PD 23) and late (PD 81) passages of cultured bowhead whale lung fibroblasts. Both early and late passage cells contain a subset of the shortest telomeres that have not been identified by TRF analysis