Table 6.

Estimated differences between treatments and the p values for sequence and period effects, from ANOVA

Variable	Mean treatment difference (ICE-CD)	p value	Sequence effect p value	Period effect p value
Temperature reduction (°C)	0.17	0.764	0.199	0.014
Cooling distribution (%)	1.11	0.446	0.169	0.174
Systolic BP change (mmHg)	−1.60	0.648	0.222	0.048
Diastolic BP change (mmHg)	−2.15	0.509	0.501	0.509
Heart rate change (beats/min)	2.60	0.208	0.767	0.882