Table 2.
Demographic characteristics and cognitive test result comparisons between control group and cognitive symptom group (SCD and MCI), as well as subgroups with mild cognitive impairment (MCI) and subjective cognitive decline (SCD)
| Control Group | Cognitive | |||
| symptom Group | ||||
| (MCI &SCD) | MCI | SCD | ||
| Age at inclusion | n = 132 | n = 299 | n = 136 | n = 163 |
| Mean (SD) | 60.4 (9.3) | 63.7 (9.4) | 65.4 (9.8) | 62.3 (8.9) |
| p < 0.001a | p < 0.001a | p = n.s.a | ||
| ηp2 = 0.026 | ηp2 = 0.064 | |||
| Female/Total | 75/132 | 155/299 | 63/136 | 92/163 |
| Percentage female | 56.8% | 51.8% | 46.3% | 56.4% |
| p = n.s.c | p = n.s.c | p = n.s.c | ||
| Education level | n = 131 | n = 298 | n = 135 | n = 163 |
| Median (IQR) | 3.0 (2.0) | 3.0 (2.0) | 3.0 (3.0) | 3.0(3.0) |
| p = n.s.b | p = n.s.b | p = n.s.b | ||
| MMSE | n = 131 | n = 296 | n = 134 | n = 162 |
| Mean (SD) | 29.4 (0.9) | 28.4 (1.7) | 27.6 (2.0) | 29.1 (1.1) |
| p < 0.001b | p < 0.001b | p < 0.05b | ||
| r = 0.278 | r = 0.514 | r = 0.126 | ||
| Clock Drawing Test | n = 130 | n = 293 | n = 134 | n = 159 |
| Mean (SD) | 4.9 (0.3) | 4.8 (0.5) | 4.7 (0.6) | 4.9 (0.3) |
| p < 0.01b | p < 0.001b | p = n.s.b | ||
| r = 0.130 | r = 0.250 | |||
| CERAD word list Learning T score | n = 130 | n = 293 | n = 133 | n = 160 |
| Mean (SD) | 56.1 (9.5) | 47.8 (13.0) | 40.9 (12.8) | 53.5 (10.2) |
| p < 0.001a | p < 0.001a | p < 0.05a | ||
| ηp2 = 0.092 | ηp2 = 0.313 | ηp2 = 0.016 | ||
| CERAD word list Recall T-score | n = 130 | n = 289 | n = 130 | n = 160 |
| Mean (SD) | 55.2 (11.2) | 46.1 (14.5) | 37.5 (14.4) | 53.0 (10.3) |
| p < 0.001a | p < 0.001a | p = n.s.a | ||
| ηp2 = 0.087 | ηp2 = 0.320 | |||
| VOSP Silhouettes T-score | n = 120 | n = 268 | n = 126 | n = 142 |
| Mean (SD) | 52.7 (8.9) | 48.2 (11.2) | 43.6 (10.9) | 52.3 (9.8) |
| p < 0.001a | p < 0.001a | p = n.sa | ||
| ηp2 = 0.038 | ηp2 = 0.175 | |||
| Trail Making Test A | n = 128 | n = 293 | n = 132 | n = 161 |
| T-score | 49.2 (9.6) | 45.0(10.2) | 40.7 (9.9) | 48.6 (8.9) |
| Mean (SD) | p < 0.001a | p < 0.001a | p = n.s.a | |
| ηp2 = 0.035 | ηp2 = 0.157 | |||
| Trail Making Test B | n = 127 | n = 293 | n = 132 | n = 161 |
| T-score | 51.6 (8.8) | 44.9 (11.7) | 39.5 (12.4) | 49.4 (9.0) |
| Mean (SD) | p < 0.001a | p < 0.001a | p < 0.05a | |
| ηp2 = 0.074 | ηp2 = 0.243 | ηp2 = 0.015 | ||
| Controlled Oral Word | n = 128 | n = 290 | n = 131 | n = 159 |
| Association Test | 50.5 (7.6) | 48.8 (10.4) | 45.5 (10.1) | 51.6 (9.8) |
| (COWAT) T-Score | p = n.s.a | p < 0.001a | p = n.s.a | |
| Mean (SD) | ηp2 = 0.072 |
The continuous variables (Age at inclusion, CERAD word list learning and recall T-score, VOSP silhouettes T-score, TMT-A and TMT-B T-score and COWAT T-score) are summarized by mean (standard deviation, SD). The ordinal variable educational level is described by median (interquartile range). Variables of assumed normal distribution are compared with one-way ANOVA with predefined contrasts and effect sizes (ηp2) are provided for significant results (a). Variables of non-normal distribution (MMSE and Clock drawing test) and the ordinal variable (education level) are compared with Mann-Whitney U tests and effect sizes (r) are provided for significant results (b). The binary variable sex is described with observed numbers and percentages and compared with Pearson’s Chi square tests (c). Significant p-values and effect sizes are shown in Bold.