Fig. 6.
Assessment of behavioral traits in Wdr47 mouse models. Mice were analyzed for behavioral anomalies using 16 tests (Dataset S11). Here, we show a selection of results for two cohorts: one male (11 mice Wdr47+/tm1b vs. 11 mice WT) and one female (5 mice Wdr47tm1a/tm1a vs. 7 mice WT). (A) Traveled distance in centimeters and numbers of rears for circadian activity recorded for 32 h and open-field activity for a duration of 30 min. (B) Learning and memory were tested using the Y maze (short-term memory), Morris water maze (spatial memory), and novel object recognition with retention time of 24 h (long-term memory). (C) Skilled movements evaluated using the MoRaG. (D) Grip strength for both forelimb and hind limb. (E) Motor coordination assessed using the notch bar. (F) Pain sensitivity evaluated by the latency to react to heat. All plots are represented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.