Fig. S10.
Additional assessment of whole-body traits in Wdr47 mice. (A) Anxiety assessed using two tests: the elevated plus maze and the open-field test. (B) Ataxic-like movements recorded using the gait analysis. (C) Pain sensitivity evaluated using the shock threshold at which the mouse reacts by flinching, vocalization, or jumping. (D) Touch sensitivity evaluated using the adhesive removal test. (E) Social behavior studied using the social interaction test. (F) Social memory tested using the social recognition test. (G) Body weight measurements in male mice at eight different time points. (H) Weight of white adipose tissue and brown adipose tissue in KO mice compared with matched WTs. (I) Behavioral assessment in aged mice (56 wk old). Comparison between forelimb strength and hind paw errors at 16 and 56 wk of age mice using eight Wdr47+/tm1a vs. eight matched WT mice (male; same cohort evaluated at both ages). Number of mice used for A–H: female: n = 5 Wdr47tm1a/tm1a, n = 7 matched WT; male: n = 12 Wdr47+/tm1a, n = 5 matched WT. All plots are represented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; #P < 0.07.