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. 2017 Nov 7;8:1349. doi: 10.1038/s41467-017-01285-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overview of synthetic data set. The top row summarizes the phantom generation process. The simulated images are generated from 25 major bundles, which are shown in the bottom part of the figure. These were manually segmented from a whole-brain tractogram of a HCP subject and include the CC, cingulum (Cg), fornix (Fx), anterior commissure (CA), optic radiation (OR), posterior commissure (CP), inferior cerebellar peduncle (ICP), middle cerebellar peduncle (MCP), superior cerebellar peduncle (SCP), parieto-occipital pontine tract (POPT), cortico-spinal tract (CST), frontopontine tracts (FPT), ILF, UF, and SLF. The connectivity plot in the middle shows the phantom design. The segment positions correspond to the involved endpoint region (from top to bottom: frontal lobe, temporal lobe, parietal lobe, occipital lobe, subcortical region, cerebellum, brain stem). The radial segment length and the connection number in the plot are chosen according to the volume of the respective bundle endpoint region. Abbreviations: right (R) and left (L) hemisphere, head (H) and tail (T) of each respective bundle