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. 2017 Nov 7;7:14779. doi: 10.1038/s41598-017-14965-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NIKtg Treg proportions and phenotype in mixed BM chimeras. Mixed BM chimeric mice were generated as described in Fig. 2 except that mixed BM recipients were Thy1.1 and WT BM was CD45.1. (a) Gating strategy and representative histograms of surface molecule expression in splenocytes. Upper left dot plot is gated on live lymphocytes. Blue lines, WT; red lines, NIKtg. (b) Quantitation of Foxp3⁺ proportion within the indicated genotype of CD4 T cells (upper left graph) and expression of CD25, CTLA-4, and CD103 on Foxp3⁺ gated cells from the indicated organs. MFI, mean fluorescence intensity; MLN, mesenteric lymph nodes; PLN, peripheral lymph nodes. Data are from one representative experiment of 3. Bar graphs depict mean +/− SD (n = 5 mice). *p < 0.05.