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. 2017 Nov 7;7:14749. doi: 10.1038/s41598-017-15246-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Glycine could promote the angiogenesis. (a) Hind-limb ischemia was created in C57 mice through femoral artery ligation. Upper: Serial laser Doppler analysis of blood perfusion in hindlimbs of mice injected with saline, glycine or VEGF at the day 3, 7 and 14. The concentration: 140 uM glycine and 20 ng/ml VEGF. The volume: 100 ul. Down: Quantitative analysis of blood flow using percentage of the ischemic limb relative to the control limb (n = 6). Results represented mean ± SEM of n independent experiments. **P < 0.01, *P < 0.05, 1-way ANOVA. (b) Representative images of in vitro tube formation in control, 140uM glycine or 20 ng/ml VEGF-treated ECs. Total sprouting length was indicated in the graph. Scale bar, 500 um (n = 5). (c) Representative images of the angiogenesis of saline, 140 uM glycine or 20 ng/ml VEGF-treated chorioallantoic membrane (CAM) (n = 6).