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. 2017 Nov 6;149(11):985–1007. doi: 10.1085/jgp.201711845

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© 2017 Zhou et al.

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Figure 1. — Components of a Slo1 α subunit and Slo1 channel. (A) Topology map of a single pore-forming Slo1 α subunit highlighting its three distinct domains, PGD (S5-pore loop-S6), VSD (S0–S4), and CTD (two RCK domains per subunit; Rothberg, 2012). (B) Schematic of modular origin of a Slo1 channel highlighting the octameric arrangement of RCK domains in the CTD. (C) Color-coded map of PGD (yellow), VSD (green), and CTD (red, RCK2; blue, RCK1) in the liganded aSlo1 structure. Ca²⁺ ions are yellow spheres, Mg²⁺ ions are red spheres, and K⁺ ions are purple spheres.