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. 2017 Nov 7;7:14624. doi: 10.1038/s41598-017-15222-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Energy metabolism is perturbed in the BCO2 KO liver. (A) Expression of proteins associated with energy metabolism, particularly lipid metabolism by immunoblotting. (B) Quantifications of listed proteins. (C) Metabolites associated with lipid metabolism. (D) Heat map of cofactors and vitamins associated with energy metabolism. Heat map only presents the significantly changes metabolites. Values are means ± SD. Data was analyzed by one-way ANOVA. n = 6. Different letters indicate significant difference between groups. P-value ≤ 0.05 is considered as significant. AMPKα, AMP activated protein kinase α; PPARα, peroxisome proliferator activated receptor α; FASN, fatty acid sunthase; HADH, mitochondrial hydroxyacyl-coenzyme A dehydrogenase; ACADL, long-chain specific acyl-CoA dehydrogenase; CPT1A, carnitine palmitoyltransferase 1α; CACT1, carnitine/acylcarnitine translocase 1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; ATP5A1, ATP synthase, H⁺ transporting, mitochondrial F1 complex, alpha subunit 1; W and WT, wild type; H and Het, BCO2 heterozygous mice; K and KO, BCO2 knockout mice.