1.

Correlation of clinicopathological parameters and BMPR2 and HIF1-α expression in patients with osteosarcoma

Variables	Total (N=103)	BMPR2 expression (n)				HIF1-α expression (n)
		Positive	Negative	P		Positive	Negative	P
BMPR2, bone morphogenetic protein receptor 2; HIF1-α, hypoxia-inducible factor 1-α.
Gender				0.994				0.102
Male	49	29	20			23	26
Female	54	32	22			34	20
Age (year)				0.478				0.158
≤20	57	32	25			28	29
>20	46	29	17			29	17
Tumor location				0.108				0.262
Femur	39	26	13			25	14
Tibia	23	13	10			9	14
Humerus	23	9	14			12	11
Others	18	13	5			11	7
Histological classification				0.543				0.361
Osteoblastic	61	34	27			37	24
Chondroblastic	25	15	10			11	14
Others	17	12	5			9	8
Grade of tumor				0.001				0.027
I	48	20	28			21	27
II+III	55	41	14			36	19
Lung metastasis				0.003				<0.001
Yes	57	41	16			44	13
No	46	20	26			13	33