3.

Predictive value of BMPR2 and HIF1-α expression in metastasis

Variables	Total (N)	Lung metastasis (n)		Area under ROC	95% CI	P
		Yes	No
BMPR2, bone morphogenetic protein receptor 2; HIF1-α, hypoxia-inducible factor 1-α; ROC, receiver operating characteristics; 95% CI, 95% confident interval; +, positive; –, negative; †, included BMPR2+HIF1-α–, BMPR2–HIF1-α+, and BMPR2–HIF1-α–.
BMPR2+	61	41	20	0.682	0.614–0.749	<0.001
BMPR2–	42	16	26
HIF1-α+	57	44	13	0.790	0.743–0.838	<0.001
HIF1-α–	46	13	33
BMPR2+HIF1-α+	39	31	8	0.854	0.816–0.892	<0.001
Others†	64	26	38