Figure 3.

Identification of MIG1-glucose-dependent genes involved in WOA sensitivity. (A) Comparison of genes found significantly regulated by MIG1 (89), presence of WOAs in YPD media (885), and carbon source in the presence of WOAs (147). A group of six genes was identified as commonly present in all three lists. (B) Mean of the RPKM values plotted according to mean growth rates of the four replicates per condition for GLG2, orf19.7566, ALD6, FDH1, HGT16, and orf19.94. Solid black lines represent linear regression. Gray error bars represent SEM. RPKM, reads per kilobase per million mapped reads; WOAs, weak organic acids; YPD, yeast extract-peptone-dextrose media; YPM, media with identical composition to YPD except d-glucose replaced by maltose.