Figure 4.

HGT16 inactivation increases acetic acid resistance. (A) Quantitative growth assays of control (SC5314) and hgt16Δ strain performed in YPD or YPM supplemented with acetic acid, at IC₅₀ value and adjusted to pH 5.5. * P < 0.05. (B) Proposed model where glucose via Mig1p inactivates HGT16 expression, which is itself stimulated by the presence of WOAs in growth medium. Production of Hgt16p could increase WOA import, which leads to a reduction in C. albicans growth rate. WOAs, weak organic acids; YPD, yeast extract-peptone-dextrose media; YPM, media with identical composition to YPD except d-glucose replaced by maltose.