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. 2017 Sep 25;89(20):11143–11150. doi: 10.1021/acs.analchem.7b03512

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Copyright © 2017 American Chemical Society

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Sensitivity of LESA-MS versus HR-LESA-μLC-MS: The total mass spectrum (a and c) and a zoomed-in mass spectrum (b and d) of the adenohypophysis region of rat pituitary gland using LESA-MS (a and b) compared to HR-LESA-μLC-MS (c and d). The zoomed mass range displays a low-intensity peak corresponding to the protonated molecule of leucine enkephalin (marked with *), which is known to be present in this region. This is extracted from the ion chromatogram at a retention time at 16 min. The zoomed mass range from HR-LESA-μLC-MS shows the presence of leucine enkephalin coeluting with a triply charged species, which was not observed with LESA-MS.