Table 4.
Relationship Between Neonatal Dysthyroidism and Predictor Variable (Maternal or Neonatal TRAb Level)
| Predictor Variable | Optimal Cutoff, IU/L | Sensitivity, % | Specificity,% | PPV, % | NPV, % | Correctly Classified % | AUC |
|---|---|---|---|---|---|---|---|
| All women (n = 417) | |||||||
| Maternal MaxTRAb | 5.9 | 100 (100–100) | 82 (78–86) | 26 (22–30) | 100 (100–100) | 83 | 0.97 (0.95–0.99) |
| Neonatal TRAb, D0–D5 | 6.8 | 100 (100–100) | 94 (92–96) | 50 (45–55) | 100 (100–100) | 92 | 0.98 (0.97–0.99) |
| Receiving ATDs during pregnancy | |||||||
| Yes (n = 145; 35.0%) | |||||||
| Maternal MaxTRAb | 5.9 | 100 (100–100) | 61 (53–69) | 29 (22–36) | 100 (100–100) | 66 | 0.93 (0.87–0.98) |
| Neonatal TRAb, D0–D5 | 6.8 | 100 (100–100) | 89 (84–94) | 59 (51–67) | 100 (100–100) | 90 | 0.97 (0.94–0.99) |
| No (n = 272; 65.0%) | |||||||
| Maternal MaxTRAb | 5.9 | 100 (100–100) | 92 (89–95) | 19 (15–23) | 100 (100–100) | 92 | 0.99 (0.97–1.0) |
| Neonatal TRAb, D0–D5 | 6.8 | 100 (100–100) | 96 (94–98) | 31 (25–37) | 100 (100–100) | 96 | 0.99 (0.99–1.0) |
Data in parentheses are 95% confidence intervals.
Abbreviation: MaxTRAb, maximum TRAb.