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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: J Med Chem. 2017 Jan 25;60(5):1665–1672. doi: 10.1021/acs.jmedchem.6b01483

Figure 6.

Figure 6

Property space for passive permeability constrained by polarity, solubility, and molecular volume. The black line represents the lipophilicity required (logKmem) to achieve a permeability of 1 × 10−6 cm/sec for a given volume. The required lipophilicity to overcome the molecular size penalty we observe places an operational limit on molecular volume ~1500 Å3 (~MW 1200).

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