Table 3. Amination of Functionalized Aryl halides with Primary Alkylamine Using (CyPF-^tBu)PdCl₂ 1^a.

entry	halide	product	catalyst loading (%)	conditions	yield (%)b
1			0.05	100 °C 48 h	84
2			0.5	100 °C 36 h	52
3c			0.5	110 °C 24 h	67
4			0.5	100 °C 24 h	77
5			0.5	100 °C 24 h	69
6			0.05	100 °C 24 h	84
7			0.05	100 °C 24h	78
8c			1.0	110 °C 24 h	75
9c			0.5	110 °C 24 h	88
10c			2.0	110 °C 48h	71
11c			1.0	110 °C 24 h	85
12c			1.0	110 °C 24 h	89

^aReactions conducted with a 1:1 ratio of metal to ligand, 1 mmol ArX, 1.2 equiv amine, and 2.4 equiv LiN(SiMe₃)₂ in 1 mL DME.

^bIsolated yield.

^cUsing K₃PO₄ as the base.