Table 2. Overall Biodistribution Results of 64Cu-Labeled L0–L5 for the Three Time Points Evaluated (2, 60, and 240 min; % Injected Dose/Gram, Mean ± SEM).
L0 2 min | L0 60 min | L0 240 min | L1 2 min | L1 60 min | L1 240 min | |
---|---|---|---|---|---|---|
blood | 7.58 ± 0.48 | 0.96 ± 0.06 | 0.88 ± 0.01 | 4.32 ± 0.46 | 0.98 ± 0.04 | 1.04 ± 0.19 |
lung | 7.49 ± 0.73 | 5.14 ± 0.23 | 5.08 ± 0.55 | 3.32 ± 0.04 | 3.67 ± 0.06 | 4.48 ± 0.31 |
liver | 5.59 ± 0.40 | 9.87 ± 0.84 | 7.71 ± 0.37 | 37.58 ± 3.18 | 18.03 ± 1.46 | 10.39 ± 0.75 |
kidney | 33.95 ± 2.09 | 8.43 ± 0.29 | 6.98 ± 0.30 | 73.56 ± 6.98 | 46.89 ± 2.99 | 27.92 ± 3.92 |
muscle | 2.55 ± 0.14 | 0.55 ± 0.03 | 0.40 ± 0.03 | 0.74 ± 0.05 | 0.55 ± 0.18 | 0.40 ± 0.05 |
brain | 0.37 ± 0.06 | 0.14 ± 0.01 | 0.20 ± 0.01 | 0.17 ± 0.02 | 0.13 ± 0.01 | 0.20 ± 0.02 |
bone | 2.66 ± 0.09 | 1.06 ± 0.09 | 0.97 ± 0.18 | 0.69 ± 0.01 | 0.68 ± 0.02 | 0.89 ± 0.11 |
tail | 15.51 ± 2.53 | 3.95 ± 0.38 | 2.00 ± 0.24 | 5.32 ± 1.72 | 2.28 ± 0.69 | 1.60 ± 0.19 |
L2 2 min | L2 60 min | L2 240 min | L3 2 min | L3 60 min | L3 240 min | |
---|---|---|---|---|---|---|
blood | 20.54 ± 1.17 | 3.66 ± 0.20 | 2.75 ± 0.20 | 12.16 ± 1.15 | 1.26 ± 0.18 | 1.43 ± 0.26 |
lung | 11.51 ± 0.83 | 6.93 ± 0.33 | 8.66 ± 0.92 | 29.25 ± 1.65 | 6.85 ± 1.44 | 7.18 ± 0.31 |
liver | 31.42 ± 5.32 | 27.13 ± 2.76 | 24.14 ± 1.55 | 38.57 ± 1.21 | 43.36 ± 6.24 | 35.11 ± 1.07 |
kidney | 31.78 ± 2.26 | 42.51 ± 1.46 | 31.10 ± 1.82 | 35.22 ± 2.13 | 22.12 ± 3.15 | 18.56 ± 2.01 |
muscle | 1.25 ± 0.11 | 0.97 ± 0.08 | 0.76 ± 0.09 | 0.77 ± 0.12 | 0.44 ± 0.04 | 0.48 ± 0.06 |
brain | 1.33 ± 0.27 | 0.27 ± 0.03 | 0.30 ± 0.01 | 0.49 ± 0.01 | 0.22 ± 0.04 | 0.21 ± 0.01 |
bone | 2.09 ± 0.21 | 1.37 ± 0.04 | 1.35 ± 0.06 | 1.30 ± 0.13 | 1.19 ± 0.33 | 1.38 ± 0.09 |
tail | 61.81 ± 4.63 | 15.52 ± 5.02 | 17.03 ± 6.21 | 15.00 ± 3.57 | 14.14 ± 3.58 | 9.12 ± 1.48 |
L4 2 min | L4 60 min | L4 240 min | L5 2 min | L5 60 min | L5 240 min | |
---|---|---|---|---|---|---|
blood | 10.93 ± 0.86 | 0.99 ± 0.08 | 0.93 ± 0.07 | 22.88 ± 2.96 | 2.53 ± 0.05 | 2.16 ± 0.03 |
lung | 7.65 ± 0.63 | 3.92 ± 0.88 | 4.21 ± 0.30 | 11.91 ± 1.82 | 7.20 ± 0.86 | 10.03 ± 0.34 |
liver | 36.53 ± 2.12 | 11.60 ± 0.93 | 9.20 ± 0.53 | 57.70 ± 4.43 | 35.83 ± 3.68 | 26.65 ± 0.17 |
kidney | 17.64 ± 0.52 | 15.53 ± 1.01 | 6.23 ± 0.27 | 79.87 ± 2.80 | 80.82 ± 12.03 | 36.69 ± 1.46 |
muscle | 1.67 ± 0.07 | 0.39 ± 0.03 | 0.38 ± 0.06 | 1.38 ± 0.09 | 0.87 ± 0.05 | 0.68 ± 0.06 |
brain | 0.61 ± 0.14 | 0.13 ± 0.01 | 0.16 ± 0.01 | 0.75 ± 0.16 | 0.26 ± 0.01 | 0.40 ± 0.03 |
bone | 2.47 ± 0.28 | 0.61 ± 0.12 | 0.66 ± 0.04 | 2.31 ± 0.30 | 1.32 ± 0.05 | 1.68 ± 0.07 |
tail | 9.20 ± 0.33 | 5.02 ± 2.02 | 2.35 ± 0.70 | 24.57 ± 9.06 | 24.83 ± 4.68 | 25.60 ± 8.33 |