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. 2017 Aug 21;139(36):12550–12558. doi: 10.1021/jacs.7b05937

Table 2. Overall Biodistribution Results of 64Cu-Labeled L0L5 for the Three Time Points Evaluated (2, 60, and 240 min; % Injected Dose/Gram, Mean ± SEM).

  L0 2 min L0 60 min L0 240 min L1 2 min L1 60 min L1 240 min
blood 7.58 ± 0.48 0.96 ± 0.06 0.88 ± 0.01 4.32 ± 0.46 0.98 ± 0.04 1.04 ± 0.19
lung 7.49 ± 0.73 5.14 ± 0.23 5.08 ± 0.55 3.32 ± 0.04 3.67 ± 0.06 4.48 ± 0.31
liver 5.59 ± 0.40 9.87 ± 0.84 7.71 ± 0.37 37.58 ± 3.18 18.03 ± 1.46 10.39 ± 0.75
kidney 33.95 ± 2.09 8.43 ± 0.29 6.98 ± 0.30 73.56 ± 6.98 46.89 ± 2.99 27.92 ± 3.92
muscle 2.55 ± 0.14 0.55 ± 0.03 0.40 ± 0.03 0.74 ± 0.05 0.55 ± 0.18 0.40 ± 0.05
brain 0.37 ± 0.06 0.14 ± 0.01 0.20 ± 0.01 0.17 ± 0.02 0.13 ± 0.01 0.20 ± 0.02
bone 2.66 ± 0.09 1.06 ± 0.09 0.97 ± 0.18 0.69 ± 0.01 0.68 ± 0.02 0.89 ± 0.11
tail 15.51 ± 2.53 3.95 ± 0.38 2.00 ± 0.24 5.32 ± 1.72 2.28 ± 0.69 1.60 ± 0.19
  L2 2 min L2 60 min L2 240 min L3 2 min L3 60 min L3 240 min
blood 20.54 ± 1.17 3.66 ± 0.20 2.75 ± 0.20 12.16 ± 1.15 1.26 ± 0.18 1.43 ± 0.26
lung 11.51 ± 0.83 6.93 ± 0.33 8.66 ± 0.92 29.25 ± 1.65 6.85 ± 1.44 7.18 ± 0.31
liver 31.42 ± 5.32 27.13 ± 2.76 24.14 ± 1.55 38.57 ± 1.21 43.36 ± 6.24 35.11 ± 1.07
kidney 31.78 ± 2.26 42.51 ± 1.46 31.10 ± 1.82 35.22 ± 2.13 22.12 ± 3.15 18.56 ± 2.01
muscle 1.25 ± 0.11 0.97 ± 0.08 0.76 ± 0.09 0.77 ± 0.12 0.44 ± 0.04 0.48 ± 0.06
brain 1.33 ± 0.27 0.27 ± 0.03 0.30 ± 0.01 0.49 ± 0.01 0.22 ± 0.04 0.21 ± 0.01
bone 2.09 ± 0.21 1.37 ± 0.04 1.35 ± 0.06 1.30 ± 0.13 1.19 ± 0.33 1.38 ± 0.09
tail 61.81 ± 4.63 15.52 ± 5.02 17.03 ± 6.21 15.00 ± 3.57 14.14 ± 3.58 9.12 ± 1.48
  L4 2 min L4 60 min L4 240 min L5 2 min L5 60 min L5 240 min
blood 10.93 ± 0.86 0.99 ± 0.08 0.93 ± 0.07 22.88 ± 2.96 2.53 ± 0.05 2.16 ± 0.03
lung 7.65 ± 0.63 3.92 ± 0.88 4.21 ± 0.30 11.91 ± 1.82 7.20 ± 0.86 10.03 ± 0.34
liver 36.53 ± 2.12 11.60 ± 0.93 9.20 ± 0.53 57.70 ± 4.43 35.83 ± 3.68 26.65 ± 0.17
kidney 17.64 ± 0.52 15.53 ± 1.01 6.23 ± 0.27 79.87 ± 2.80 80.82 ± 12.03 36.69 ± 1.46
muscle 1.67 ± 0.07 0.39 ± 0.03 0.38 ± 0.06 1.38 ± 0.09 0.87 ± 0.05 0.68 ± 0.06
brain 0.61 ± 0.14 0.13 ± 0.01 0.16 ± 0.01 0.75 ± 0.16 0.26 ± 0.01 0.40 ± 0.03
bone 2.47 ± 0.28 0.61 ± 0.12 0.66 ± 0.04 2.31 ± 0.30 1.32 ± 0.05 1.68 ± 0.07
tail 9.20 ± 0.33 5.02 ± 2.02 2.35 ± 0.70 24.57 ± 9.06 24.83 ± 4.68 25.60 ± 8.33