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. 2017 May 22;2:13. doi: 10.1038/s41536-017-0018-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The cell of origin of cholangiocarcinoma. Schematic micrograph of lineage tracing experiments in mouse demonstrating the contribution of cytokeratin-19-positive ductular cells and albumin or transthyretin-positive hepatocytes to the formation of tumours exhibiting biliary differentiation. Cholangiocarcinoma can arise from either cholangiocytes, immature ductules or through transdifferentiation of hepatocytes