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. 2017 Jul 27;2:22. doi: 10.1038/s41536-017-0027-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Macrophage depleted animals feature enhanced fibroblast differentiation and collagen maturation. a Alpha smooth muscle actin (αSMA) positive myofibroblasts populated the cryo-lesion in Clo-Lipo treated animals where αSMA + cells were restricted to the epicardium in PBS-Lipo control lesioned animals at 7 dpi. b Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) expression was up-regulated in Clo-Lipo treated animals 7 dpi at different sites at along the wound margin. c Dissected 14 dpi cryo-injured whole mounted hearts imaged under a polarizing lens at maximum contrast. Clo-Lipo hearts showed enhanced accumulation of cross-linked collagen (top panel) Picrosirius red stained sections visualized under polarized light showed accumulation of thick collagen bundles in Clo-Lipo treated animals at 14 dpi. Scale bar = 100 μM