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. 2017 Apr 13;2:11. doi: 10.1038/s41525-017-0016-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — PC analysis of comprehensive DNAm profiles. The x-axis and y-axis represent the first and second PC, respectively. Monocytes are indicated in red, while CD4⁺ T cells are indicated with a colour gradient according to the median DNAm level of GATA3 binding sites, ranging from low (purple) to high (green). GATA3 is involved in the specification of naive CD4⁺ T cells to Th2 cells and therefore, the median DNAm level of GATA3 binding sites is expectedly negatively correlated with the proportion of Th2 cells