TABLE 2 .
Prevalence of pneumococcal nasopharyngeal colonization in PCV7-vaccinated and PCV-unvaccinated, HIV-uninfected children as measured by quantitative qPCR
| Pneumococcusa | Prevalence in 9-mo-old childrenb |
OR (95% CI), P valuec |
aORd (95% CI), P value |
Prevalence in 16-mo-old children |
OR (95% CI), P value |
aOR (95% CI), P value |
||
|---|---|---|---|---|---|---|---|---|
| PCV7- unvaccinated (n = 181) |
PCV7- vaccinated (n = 175) |
PCV7- unvaccinated (n = 193) |
PCV7- vaccinated (n = 164) |
|||||
| lytA | 150 (82.9) | 125 (71.4) | 0.52 (0.31–0.86), P = 0.01 |
0.45 (0.23–0.87), P = 0.01 |
157 (81) | 123 (75) | 0.68 (0.41–1.14), P = 0.147 |
0.55 (0.29–1.03), P = 0.06 |
| VT serotypes | 112 (61.9) | 63 (36) | 0.35 (0.21–0.58), P < 0.001 |
0.37 (0.19–0.7), P = 0.002 |
100 (51.8) | 54 (32.9) | 0.44 (0.27–7.01), P < 0.001 |
0.41 (0.26–0.63), P = 0.007 |
| NVT serotypes | 54 (33.7) | 70 (40) | 1.74 (1.08–2.82), P = 0.002 |
1.88 (1.02–3.48), P = 0.02 |
73 (37.8) | 102 (62.2) | 1.81 (1.12–2.93), P < 0.001 |
2.2 (1.18–4.1), P = 0.01 |
Streptococcus pneumoniae carrying the lytA gene or S. pneumoniae serotypes. PCV7 (7-valent pneumococcal conjugate vaccine) serotypes/serogroups (VT) include 4, 6A/B, 9A/L/N/V, 14, 18 A/B/C, 19B/F, and 23F. Nonvaccine serotypes/serogroups (NVT) are 1, 3, 5, 6 C/D, 7C, 10A, 11A/B/C/D/F, 12A/B/F, 13, 15 A/B/C/F, 16F, 17F, 19A, 20, 21, 23A/B, and 34/37/17A.
Prevalence of pneumococcal nasopharyngeal colonization in 9-month-old or 16-month-old children vaccinated or not vaccinated with PCV7. The number of children colonized with pneumococcus is shown. The percentage of children colonized is shown in parentheses.
The odds ratio (OR), the 95% confidence interval (95% CI) for the odds ratio (shown in parentheses), followed by the P value.
The adjusted odds ratio (aOR) for pneumococcal colonization was determined by multivariate logistic regression, controlling for race, smoking household contact, co-trimoxazole use, day care attendance, and mean age at the time of sample collection.