TABLE 3 .
Density of pneumococcal nasopharyngeal carriage in PCV7-vaccinated and PCV7-unvaccinated, HIV-uninfected children as measured by quantitative PCR
| Pneumococcus | GMD (95% CI)a in 9-mo-old children |
P value | GMD (95% CI) in 16-mo-old children |
P value | ||
|---|---|---|---|---|---|---|
| PCV7-unvaccinated (n = 181) |
PCV7-vaccinated (n = 175) |
PCV7-unvaccinated (n = 193) |
PCV7-vaccinated (n = 164) |
|||
| Pneumococcus (LytA) | 4.28 (4.09 to 4.47) | 4.68 (4.45 to 4.90) | 0.007 | 4.33 (4.16 to 4.5) | 4.44 (4.23 to 4.66) | 0.53 |
| Vaccine serotypes/ serogroups |
3.4 (3.2 to 3.6) | 3.8 (3.5 to 4.1) | 0.048 | 3.59 (3.36 to 3.83) | 3.73 (3.4 to 4.0) | 0.48 |
| 4 | 3.8 | 2.18 (−2.1 to 6.47) | 4.53 | – | ||
| 6A/B | 4.41 (4.0 to 4.82) | 4.41 (3.9 to 4.92) | 0.99 | 4.17 (3.66 to 4.68) | 4.0 (3.44 to 4.58) | 0.68 |
| 9A/L/N/V | 2.52 (1.96 to 3.08) | 2.84 (1.48 to 4.19) | 0.52 | 2.36 (1.77 to 2.96) | 3.99 (0.81 to 6.04) | 0.09 |
| 14 | 2.46 (1.7 to 3.22) | 3.66 (−0.68 to 6.65) | 0.15 | 3.29 (2.68 to 3.91) | 2.75 (1.29 to 4.20) | 0.37 |
| 18A/B/C | 2.80 (2.26 to 3.49) | 1.96 | 3.58 (2.51 to 4.65) | 4.30 (3.36 to 5.25) | 0.32 | |
| 19B/F | 3.36 (2.99 to 3.74) | 3.79 (3.28 to 4.3) | 0.16 | 3.52 (3.12 to 3.96) | 3.65 (3.12 to 4.17) | 0.71 |
| 23F | 2.9 (2.59 to 3.4) | 3.76 (2.24 to 5.28) | 0.84 | 3.04 (2.67 to 3.4) | 3.44 (2.45 to 4.44) | 0.71 |
| Nonvaccine serotypes/ serogroups |
3.1 (2.7 to 3.4) | 3.6 (3.0 to 3.4) | 0.018 | 3.33 (3.0 to 3.66) | 3.74 (3.42 to 4.06) | 0.08 |
| 1 | 2.31 | 2.29 (−1.03 to 5.61) | 3.47 (−11.4 to 8.31) | 1.99 | ||
| 3 | 5.13 | 3.55 | – | – | ||
| 5 | 2.0 (1.63 to 2.36) | 2.29 (1.85 to 2.7) | 0.23 | 2.01 (1.83 to 2.19) | 2.79 (1.53 to 4.04) | 0.015 |
| 6C/D | 4.2 (−25.5 to 33.94) | 2.76 (1.71 to 3.81) | 0.60 | 2.99 (2.32 to 3.67) | 3.99 (−12.12 to 0.1) | 0.38 |
| 7C | 3.25 | 3.13 (0.5 to 5.76) | 1.57 | 2.66 (1.51 to 3.79) | ||
| 10B | 4.15 (−10.47 to 8.78) | 3.09 | 4.65 (4.0 to 5.3) | 3.26 (2.15 to 4.36) | 0.06 | |
| 11A/B/C/D/F | 1.79 (−2.66 to 6.24) | 2.67 (1.32 to 4.0) | 0.34 | 2.88 (1.9 to 3.87) | 4.06 (0.82 to 7.3) | 0.23 |
| 12A/B/F | 2.44 | 3.38 (1.39 to 5.38) | – | – | ||
| 13 | 2.99 (0.22 to 6.01) | 4.7 (2.86 to 6.54) | 0.21 | 2.84 (1.08 to 4.61) | 3.21 (1.38 to 5.04) | 0.65 |
| 15A/B/C/F | 3.66 (3.11 to 4.2) | 4.1 (3.4 to 4.79) | 0.27 | 3.88 (3.23 to 4.53) | 4.03 (3.27 to 4.79) | 0.75 |
| 16F | 3.26 (2.24 to 4.28) | 3.65 (2.4 to 4.89) | 0.65 | 4.84 (2.67 to 7.01) | 5.07 (2.77 to 7.37) | 0.84 |
| 17F | – | 3.10 (−1.31 to 7.5) | 2.48 (−12.1 to 7.05) | 0.72 | ||
| 19A | 2.83 (2.26 to 3.7) | 3.76 (3.36 to 4.1) | 0.046 | 3.04 (2.26 to 3.83) | 4.15 (3.66 to 4.64) | 0.013 |
| 20 | 4.20 (2.33 to 6.07) | 2.01 | – | – | ||
| 21 | 3.62 (−0.65 to 7.89) | 3.32 (−13.7 to 0.36) | 0.87 | 5.22 | 2.82 (1.82 to 3.8) | |
| 23A/B | 2.07 (1.48 to 2.67) | 4.48 (0.82 to 8.14) | 0.002 | 1.58 (1.28 to 1.87) | 3.59 (0.88 to 6.32) | 0.013 |
| 34/37/17A | 2.83 (1.33 to 4.34) | 3.76 (2.24 to 5.28) | 0.84 | 4.34 (0.50 to 8.17) | 4.67 (3.7 to 5.61) | 0.71 |
a
The geometric mean density (GMD) of carriage and 95% confidence intervals (95% CI) were calculated following log10 transformations and compared with multivariate analysis controlling for race, smoking household contact, co-trimoxazole use, day care attendance, and mean age at time of sample collection. PCV7, 7-valent pneumococcal conjugate vaccine. −, too few observations to calculate the P value.