TABLE 4 .
Cocolonization by vaccine types and nonvaccine type pneumococcus in HIV-uninfected children as measured by quantitative molecular PCR
| Pneumococcal colonizationa | Cocolonizationb in 9-mo-old children |
P valuec | Cocolonization in 16-mo-old children |
P value | ||
|---|---|---|---|---|---|---|
| PCV7-unvaccinated (n = 181) |
PCV7-vaccinated (n = 175) |
PCV7-unvaccinated (n = 193) |
PCV7-vaccinated (n = 164) |
|||
| Total | 150 (82.9) | 125 (71.4) | 0.01 | 157 (81.3) | 123 (75) | 0.06 |
| Not typeabled | 14 (9.3) | 22 (17.6) | 0.09 | 29 (18.5) | 29 (23.4) | 0.88 |
| Single carriers | 97 (64.6) | 74 (59.2) | 0.025 | 79 (50.3) | 55 (44.7) | 0.019 |
| Multiple carriers | 39 (26) | 29 (23.2) | 0.87 | 49 (31.2) | 39 (31.7) | 0.63 |
| +1 VT | 12 (30.7) | 4 (13.8) | 0.002 | 11 (22.4) | 1 (2.6) | 0.005 |
| VT and NVT | 26 (66.7) | 18 (62.1) | 0.006 | 31 (63.2) | 21 (55.3) | 0.004 |
| +1 NVT | 1 (2.6) | 7 (24.1) | 0.015 | 7 (14.3) | 16 (42) | 0.002 |
The total colonizing pneumococci isolated, including nontypeable pneumococci, single carriers, and multiple carriers (carrying more than one VT, VT and NVT, and more than one NVT). VT, vaccine serotypes/serogroups (4, 6A/B, 9A/L/N/V, 18A/B/C, 19B/F, and 23F). NVT, nonvaccine serotypes/serogroups (1, 3, 5, 6 C/D, 7C, 10A, 11A/B/C/D/F, 12A/B/F, 13, 15 A/B/C/F, 16F, 17F, 19A, 20, 21, 23A/B, and 34/37/17A).
The number of children (percentage shown in parentheses) cocolonized who had not been vaccinated or had been vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7).
The P values were determined by multivariate logistic regression, controlling for race, smoking household contact, co-trimoxazole use, day care attendance, and mean age at time of sample collection. P values of <0.05 were considered significant.
Nontypeable, lytA-positive, serotype-negative samples.