Figure 6.

The effect of repeated OG administration of l-Phe on food intake, body weight and gut hormones in DIO mice. The effect of repeated OG of vehicle (10% TWEEN20 in water) or 12 mmol kg⁻¹ l-Phe on (a) cumulative food intake, (b) body weight change, (c) plasma leptin, (d) acylated ghrelin, (e) GLP-1 and (f) PYY following twice daily OG during days 0–3 and three times daily OG during 4–7 days of chronic study. Dotted line highlights the start of three times daily injection. Plasma gut hormones and leptin levels were measured 24 h following the completion of the chronic administration in ad libitum-fed DIO mice. n=10 per group. *P<0.05, ***P<0.001 vs vehicle. All data expressed as mean±s.e.m.