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CB1 mediates HFS-LTD. Two candidate receptors that could act as a presynaptic target for eCBs include TRPV1 and CB1. A, The TRPV1 antagonist capsazepine failed to block LTD, suggesting that TRPV1 is not involved in this HFS-LTD (n = 9; p > 0.05 compared with control LTD). B, The CB1 antagonist AM-251 significantly blocked LTD (n = 9, p < 0.05 compared with control LTD).
