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HFS-LTD is blocked in CB1 knock-out mice. A, HFS induced a significant LTD in heterozygous mice compared with baseline (n = 7, p < 0.05). B, In CB1−/−, HFS failed to produce LTD, further demonstrating the importance of CB1 in this plasticity (n = 9, p < 0.05 compared with CB1+/−).
