Table 2.

Gene set enrichment analysis of T3-regulated genes. The table shows specific pathways and the main processes for which genes participate in each tissue.

Pathway T3 specific	Main Theme	Cerebellum	Thalamus-p	Liver
Lysine metabolism	Amino acid metabolism
Phenylalanine and Tyrosine metabolism		*
Ubiquitin-dependent Protein Degradation				*
Amino sugars synthesis	Carbohydrate metabolism			*
Galactose metabolism			*	*
Mannose metabolism			*
L-sugars oxidation			*
N-Glycan biosynthesis				*
Adherens Junction Regulation	Cell community			*
Gap Junction Regulation		*	*	*
Focal Junction Assembly			*
Tight Junction Assembly (Occludin)				*
TLR -> AP-1 signalling		*
TNFR -> CREB/ELK-SRF signaling		*
Apoptosis	Cell growth and death	*
Cleavage of Lamina in Apoptosis			*
AGER -> CREB/SP1 signalling	Cell signalling		*
AngiopoietinR -> STAT signalling			*
CannabinoidR -> AP-1/EGR signaling				*
CCR1 -> STAT signalling			*
CCR2/5 -> STAT signalling			*
CCR5 -> TP53 signalling			*
CD19 -> AP-1/ELK-SRF signalling				*
CholinergicRm -> CREB/ELK-SRF signaling				*
EctodysplasinR -> AP-1 signalling		*
EctodysplasinR -> LEF1 signalling		*
EGFR -> CTNND signalling			*
EGFR/ERBB2 -> CTNNB signalling			*
EGFR -> SMAD1 signalling			*
EGFR -> ZNF259 signalling			*
EphrinR -> actin signalling				*
ErythropoietinR -> ELK-SRF/FOS signalling				*
FcIgER -> NFATC1 signalling				*
FGFR1 -> STAT signalling				*
Guanylate Cyclase Pathway				*
IL1R -> STAT3 signalling			*
IL8R -> CREB/EGR signalling				*
NeuropeptideYR -> ATF/CREB signalling				*
NeurotensinR -> ELK-SRF/AP-1/EGR signalling				*
NTRK -> FOXO/MYCN signalling				*
OxytocinR -> ELK-SRF/GATA/AP-1 signalling				*
SerotoninR1 -> FOS signalling				*
TachykininR -> ELK-SRF signalling				*
ThromboxaneR -> CREB signalling			*
TNFRSF1A -> STAT signalling				*
VasopressinR2 -> MEF/MYOD/NFATC/MYOG signalling			*
VEGFR -> NFATC signalling			*
Single-Strand Nucleotide Excision DNA Repair	DNA replication and repair			*
Pyruvate metabolism	Energy metabolism		*
Tricarboxylic acid cycle				*
AGER -> NF-kB signalling	Immune system		*	*
Alternative Complement Pathway				*
B-cell receptor -> NF-kB signalling				*
B-cell receptor -> NFATC signalling				*
CD19 -> NF-kB signalling			*
Classical Complement Pathway			*
EctodysplasinR -> NF-kB signalling		*
FibronectinR -> NF-kB signalling			*
GHR -> NF-kB signalling			*	*
IL12R -> NF-kB/NFATC signalling			*
IL15R -> NF-kB/NFATC signalling			*	*
IL7R -> FOXO/NF-kB signalling			*	*
Lectin-induced Complement Pathway				*
MacrophageR -> CEBPB/NF-kB signalling				*
Mast Cell Activation				*
NK Cell Activation				*
PTAFR -> NF-kB signalling			*
T Cell Activation				*
T-cell receptor -> AP-1 signalling				*
T-cell receptor -> NF-kB signalling		*		*
T-cell receptor -> NFATC signalling				*
TLR4/5/7/9 -> NF-kB signalling		*
Ganglioside-type glycosphingolipid biosynthesis	Lipid metabolism			*
Globoside-type glycosphingolipid biosynthesis				*
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis				*
Metabolism of triacylglycerols			*
Omega-6-fatty acid metabolism			*
Sphingolipid metabolism				*
Purine metabolism	Nucleotide metabolism			*
Ascorbate biosyntesis	Other		*
Extracellular Matrix Turnover			*
Ethanol metabolism			*
Gonadotrope Cell Activation				*
Melanogenesis		*	*	*
Skeletal Myogenesis Control		*		*
Histone Ubiquitination	Transcription			*
Lacto- and neolacto-type glycosphingolipid biosynthesis				*
RNA Gene Silencing				*
mRNA Degradation				*
Secretory Pathway: Golgi Transport				*