Table 3.

Pathways affected by both TH treatments. Enrichment analysis for transcripts regulated by both thyronines. The table shows specific pathways and the main processes for which genes participate in each tissue.

Pathway non-specific	Main Theme	T2 Cerebellum	T3 Cerebellum	T2 Thalamus-p	T3 Thalamus-p	T2 Liver	T3 Liver
Methionine metabolism	Amino acid metabolism			*		*	*
Selencompound biosynthesis						*	*
Tryptophan metabolism						*	*
Cell Cycle Regulation	Cell growth and death					*	*
Centriole Duplication and Separation						*	*
Kinetochore Assembly						*	*
Sister Chromatid Cohesion						*	*
Intermediate Filament Polymerization	Cell motility			*	*	*
Atlas of signalling	Cell signalling					*	*
EphrinB -> JUN signalling			*	*
GRM1/5 -> CREB signalling				*			*
Coagulation Cascade	Circulatory system		*		*	*	*
Hedgehog Pathway	Development			*		*	*
Chromosome Condensation	DNA replication and repair		*			*
Direct DNA Repair						*	*
DNA Replication						*	*
Double Strand DNA Homologous Repair						*	*
Single-Strand Base Excision DNA Repair						*	*
Single-Strand Mismatch DNA Repair					*	*	*
TNFR -> NF-kB signalling	Immune system	*	*
Biosynthesis of cholesterol	Lipid metabolism					*	*
Metabolism of glycerophospholipids and ether lipids		*			*
Mevalonate pathway						*	*
Mitochondrial DNA Replication and Transcription	Mitochondrial processes					*	*
Mitochondrial Protein Transport						*	*
Mitochondrion Fusion and Fission					*	*
Pyrimidine metabolism	Nucleotide metabolism					*	*
Nuclear Envelope	Other				*	*
Pterine biosynthesis		*	*
Skeletal Myogenesis Control			*				*
Histone Acetylation	Transcription					*	*
Histone and DNA Methylation						*	*
Histone Phosphorylation						*	*
Histone Sumoylation						*	*
INO80 Chromatin Remodeling						*	*
TRRAP/TIP60 Chromatin Remodeling						*	*
Co-translational ER Protein Import	Translation					*	*
Protein Folding						*	*
Protein Nuclear Import and Export						*	*
Translation						*	*