Table 4.

Pathways affected by clusters of TH-regulated genes. Gene set enrichment analysis for regulated transcripts by clusters. The table shows the main “themes” or processes represented by the transcriptome analysis in each tissue.

	Liver								Thalamus-pituitary								Cerebellum
	T2/T3 Down	T2/T3 Up	T2 down	T3 down	T2 up	T3 up	T2 down/T3 up	T2 up/T3 down	T2/T3 Down	T2/T3 Up	T2 down	T3 down	T2 up	T3 up	T2 down/T3 up	T2 up/T3 down	T2/T3 Down	T2/T3 Up	T2 down	T3 down	T2 up	T3 up	T2 down/T3 up
Amino acid metabolism	*	*				*			*								*				*	*
Carbohydrate metabolism	*
Cell community	*	*	*		*				*		*						*
Cell growth and death	*	*	*	*	*		*		*		*	*		*		*	*	*	*	*		*
Cell motility	*								*				*				*	*
Cell signalling	*				*								*		*					*
Circulatory system	*		*						*		*						*
Development	*								*	*				*			*
Differentiation	*								*								*
DNA replication and repair	*	*	*		*				*				*
Energy metabolism	*	*
Immune system	*	*	*	*	*				*								*			*	*		*
Lipid metabolism	*		*				*		*								*	*
Membrane transport	*	*							*								*
Mitochondrial processes	*	*																	*
Nervous system	*								*								*			*
Transcription	*	*		*	*		*	*	*								*				*
Translation	*	*			*		*	*	*							*	*		*	*
Xenobiotics													*
Other	*	*			*				*	*							*	*		*		*