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. 2017 Nov 8;7:15035. doi: 10.1038/s41598-017-14778-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan plot of imputed data (a) Idiopathic osteonecrosis of the femoral head vs BioBank Japan (BBJ), (b) alcohol-associated osteonecrosis of the femoral head (ONFH) vs BBJ, (c) alcohol-associated ONFH vs BBJ of heavy drinker (400 ml/day or more ethanol consumption), (d) steroid-associated ONFH vs BBJ, and (e) neither-associated ONFH vs BBJ. The SNPs with genome-wide significance were identified in (a) 12q24.11–12 and 20q12, (b) 12q24.11–13 and 20q12, (c) 20q12, and (d) 2q32 and 6p21. The red and blue lines represented the threshold of genome-wide significance (P = 5 × 10⁻⁸) and suggestive association threshold (P = 1 × 10⁻⁵), respectively.