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. 2017 Nov 8;7:15047. doi: 10.1038/s41598-017-15404-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The association between L. reuteri colonization and infant crying time. (A) Crying time in infants colonized (n = 12) and not colonized (n = 44) by L. reuteri. Infants were categorized as colonized or not colonized by L. reuteri at both time points by L. reuteri colonization status at day 28. Bars represent median ± interquartile range. Differences within groups (day 0 to day 28) were assessed using Wilcoxon signed-rank test and differences between groups (colonized and not colonized) using Mann-Whitney U test. (B) The relationship between crying time and L. reuteri colonization density (n = 13); Spearman’s rank correlation coefficient, r = 0.68; P = 0.01.