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. 2017 Nov 8;7:15042. doi: 10.1038/s41598-017-14886-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fold change of mRNA expressions of the innate immune response genes in HCV infected cells after treating with the NS5A-bound-transbodies and controls (pegylated-IFNα-2a + RBV, telaprevir and medium alone) in comparison to normal (non-infected) cells. Panels A–C show fold change of expressions of IRF3, IFN-B and IL-28, respectively, after exposure to the transbodies and controls. The NS5A-bound-R9-HuscFvs and positive inhibitor controls restored the expressions of the innate genes that had been suppressed by the replicating HCV. All studied genes in the HCV infected cells cultured in medium alone were down-regulated by the infection.