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. 2017 Oct;183:8–16. doi: 10.1016/j.clim.2017.06.005

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 1 — Diversification features of fetal B cell repertoire. a. Spectratyping analysis of IGHV1-6 families in fetal liver (FL) GA 15^+ 3 weeks, fetal bone marrow (FBM) GA 15^+ 3 weeks, cord blood (CB) and adult peripheral blood (aPB) B-cells. b. IGHV gene (the top 25 out of 52 VH genes are shown) c. IGHD gene (the top 15 out of total 25 JH genes are shown) d. IGHJ gene and e. CDR3 aa length repertoires counted in unique clonotypes in the 4 different fetal and postnatal developmental stages (cPB: child peripheral blood). b–e: mean values with SD are shown, except in d & e where error bars are omitted for simplicity. (***p < 0.001, ****p < 0.0001).