Table 1.

Summary of cannabinoids

Generic name	Trade name	Administration method	Formulation	Dosage	Pharmacokinetics
Dronabinol	Marinol	Oral capsule	Synthetic THC	2.5 mg, 5 mg, 10 mg	tmax=2–4 hr. Completely absorbed (90–95%) after a single dose Alpha (plasma) half-life: 4 hr Beta (tissue) half-life: 25–36 hr*
Nabilone	Cesamet	Oral capsule	Synthetic structural analogue of THC Methylgroup at C9 and pentyl side chain in THC substituted with a ketone group and a dimethyl heptyl side chain respectively.	1 mg	tmax=2 hr Alpha (plasma) half-life: 2 hr Beta (tissue) half-life: 35 hr*
Nabiximols	Sativex	Oromucosal spray	Whole plant cannabis extract	2.7 mg THC and 2.5 mg CBD, per spray (100 μl)	tmax=98–253 min Variable plasma half-life of 85–130 min Clearance within 12–24 hr after dose*
CBD	None	Oral capsule	Cannabis plant extract	Variable	No available information in humans4)
THC	Namisol	Oral capsule	Cannabis plant extract	Variable	tmax=1–2 hr Half-life: 72–80 min5,6)

THC, tetrahydrocannabinol; CBD, cannabidiol.

^*Marinol (Abbott Products, 2010), Cesamet (Valeant Canada, 2009), and Sativex (GW Pharmaceutical, 2010).