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. 2017 Nov 30;15(4):313–319. doi: 10.9758/cpn.2017.15.4.313

Fig. 2.

Fig. 2

The maturation of microRNAs (miRNAs) in the cytoplasm. Dicer and its co-factor trans-activator RNA binding protein (TRBP) perform cleavage. Mature miRNAs incorporate to RNA-induced silencing complex (RISC). miRNAs usually point mRNAs 1) to degrade or 2) prevents them from translation. In rare cases miRNAs may 3) increase gene expression.