Table 1.
Importance of microRNAs subject to this review
MicroRNA | Psychiatric disorder | Importance |
---|---|---|
miR-320 | Major depression | miR-320 family may be important as a peripheral biomarker |
Autism | miR-320 was dysregulated in lymphoblastoid cell lines of autism patients | |
miR-106 | Major depression | miR-106a-5p levels was higher in depressed patients |
Schizophrenia | miR-106b-5p levels was higher in schizophrenia patients | |
Attention deficit hyperactivity disorder | Lower miR-106b-5p levels were determined in the control group | |
Autism | miR-106-5p showed higher expression in autism | |
miR-34 | Major depression | miR-34b-5p and miR-34c-5p levels in peripheral blood leukocytes were closely related to suicide idea and cognitive function |
Schizophrenia | miR-34 were presented as peripheral biomarkers | |
Bipolar disorder | miR34-a may be critical for bipolar disorder in terms of neurodevelopment | |
Alzheimer’s disease | miR-34a was observed to be decreased in plasma and cerebrospinal fluid according to the control group | |
miR-223 | Major depression | miR-223-3p levels were reported to be significantly higher in patients than in controls |
Posttraumatic stress disorder | miR-223 could be a potential biomarker | |
miR-107 | Amnestic mild cognitive impairment | miR107 expressions in plasma had a high capability to distinguish individuals with amnestic mild cognitive impairment from healthy controls |
Major depression | Positive correlation between N1, P2latency of P300 and miR-107 in depressed patients | |
miR-134 | Mild cognitive impairment | miRNA biomarker pairs successfully detected MCI in most of the patients at asymptomatic stage |
Bipolar disorder | Decreased miR-134 level was directly associated with bipolar disorder |