Table 3. Diagnostic test evaluation of anti-HCV, HCV Ag and combination of anti-HCV and HCV Ag tests to predict HCV active infection in community screening.
| % Sensitivity (95% CI) | % Specificity (95% CI) | % Positive predictive value (95% CI) | % Negative predictive value (95% CI) | % Accuracy (95% CI) | |
|---|---|---|---|---|---|
| Anti-HCV (S/CO = 5.0) | 100.0 (98.4–100.0) | 55.9 (43.3–67.9) | 88.1 (83.4–91.8) | 100.0 (90.7–100.0) | 89.7 (85.6–92.9) |
| HCV Ag (3 fmol/L) | 99.1 (96.8–99.9) | 100.0 (94.7–100.0) | 100.0 (98.3–100.0) | 97.1 (90.1–99.7) | 99.3 (97.5–99.9) |
| Anti-HCV (S/CO = 5) plus HCV Ag (3 fmol/L)a | 99.1 (96.8–99.9) | 100.0 (94.7–100.0) | 100.0 (98.3–100.0) | 97.1 (90.1–99.7) | 99.3 (97.5–99.9) |
Notes.
a
Anti-HCV (S/CO ≥ 5) plus HCV Ag (≥3 fmol/L) and others.