Table 2.

Composition and observed responses in Box–Behnken design

Batch	Independent variables			Dependent variables
	X1 (%)	X2 (%)	X3 (%)	Y1(%)	Y2(%)	Y3(%)	Y4(%)
1	0	0	0	38.3 ± 0.2	69.21 ± 0.32	0.11 ± 0.05	0.81 ± 0.01
2	0	1	1	35.1 ± 0.1	72.32 ± 0.24	0.32 ± 0.02	1.22 ± 0.12
3	0	0	0	40.2 ± 0.1	70.11 ± 0.11	0.11 ± 0.03	0.91 ± 0.08
4	0	0	0	36.3 ± 0.3	69.21 ± 0.54	0.23 ± 0.09	0.87 ± 0.03
5	0	− 1	1	33.4 ± 0.2	67.43 ± 0.42	0.65 ± 0.04	2.16 ± 0.23
6	0	0	0	37.1 ± 0.1	70.09 ± 0.27	0.12 ± 0.01	0.83 ± 0.07
7	−1	− 1	0	21.1 ± 0.2	66.22 ± 0.19	0.83 ± 0.08	2.68 ± 0.42
8	0	0	0	35.2 ± 0.1	71.34 ± 0.12	0.15 ± 0.03	0.95 ± 0.05
9	−1	1	0	24.1 ± 0.3	72.29 ± 0.82	0.47 ± 0.02	1.52 ± 0.11
10	1	1	0	33.7 ± 0.5	73.44 ± 0.47	0.29 ± 0.02	0.94 ± 0.04
11	0	1	−1	37.5 ± 0.1	73.78 ± 0.26	0.51 ± 0.05	1.82 ± 0.19
12	1	0	1	35.2 ± 0.7	71.35 ± 0.18	0.13 ± 0.01	0.86 ± 0.07
13	-1	0	-1	30.1 ± 0.5	69.28 ± 0.43	0.56 ± 0.07	1.98 ± 0.42
14	-1	0	1	25.2 ± 0.8	69.42 ± 0.35	0.42 ± 0.05	1.78 ± 0.09
15	0	-1	-1	30.6 ± 0.2	66.37 ± 0.93	0.95 ± 0.03	3.13 ± 0.64
16	1	0	-1	32.2 ± 0.8	71.92 ± 0.22	0.46 ± 0.01	1.64 ± 0.29
17	1	-1	0	22.8 ± 0.9	66.56 ± 0.39	0.53 ± 0.05	2.13 ± 0.56