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. 2017 Nov 7;5:81. doi: 10.1186/s40478-017-0481-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CLU expression reduces TDP-43 toxicity in Drosophila motor neurons. Time-dependent differences between Drosophila expressing TDP-43 +/− CLU in (a) motor function, measured by climbing assay, and (b) survival, compared to non-transgenic (Non-TG) Drosophila. In (a) and (b), values shown are means +/− SEM, and in each case the results shown are representative of three independent experiments. Parent lines used in crosses indicated in key. Differences in climbing index between genotypes were analysed by ANOVA (n = 30). Lifespans were analysed by Kaplan Meier statistics (n = 90). See also Additional file 1: Figure S7