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. 2017 Nov 7;48:73. doi: 10.1186/s13567-017-0477-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Lung lesion from cattle naturally infected with M. bovis. (A–B) H&E (A) and Masson-Goldner’s Trichrome (B) staining of a typical tuberculous classical granuloma lesion (white arrow) with central mineralization and peripheral fibrous capsule surrounded by satellites smaller lesions (black arrows). *: caseous necrosis, #: fibrous capsule. C, D Higher magnification of A and B showing an intact neutrophil area (“N” & Zoom) below the fibrous capsule (#) interspersed by foamy and epitheliod macrophages (“M”). E, F H&E (E) and Masson-Goldner’s Trichrome (F) staining of extended lesion with abundant caseous necrosis and karyorrhectic debris areas (“K”) but low discontinuous fibrous capsule (#), representative of an invasive necrotizing granuloma. G, H Higher magnification of E&F showing an example of a satellite aggregate of necrotic neutrophil (“N”, zoomed in (H)) next to the karyorrhectic debris (“K”) and caseous necrotic rich area (*). I High magnification of a foamy macrophages and epitheliod cell dense area containing multinucleated Langhans giant cells (black arrows). J Ziehl staining, high magnification of a central necrotic area showing extracellular bacilli within cellular debris. Scale bars: 25 μm (D-Zoom & H-Zoom); 50 μm (I and J); 100 μm (C, G, D, H); 200 μm (A, B, E).