Table 4.

Trial enrichment example—tabulation of mean predicted probabilities of a 30% decline of eGFR as a function of baseline TKV within eGFR and age categories

Time (yr)	Predicted probabilities of a 30% decline of eGFR
	TKV ≥ 1000 ml				TKV < 1000 ml
	eGFR < 50 (ml/min per 1.73 m2)		eGFR ≥ 50 (ml/min per 1.73 m2)		eGFR < 50 (ml/min per 1.73 m2)		eGFR ≥ 50 (ml/min per 1.73 m2)
	Age ≥ 40 yr	Age < 40 yr	Age ≥ 40 yr	Age < 40 yr	Age ≥ 40 yr	Age < 40 yr	Age ≥ 40 yr	Age < 40 yr
1	2.10%	1.80%	1.60%	1.50%	0.90%	0.80%	0.83%	0.85%
2	4.70%	4.10%	3.70%	3.40%	2.10%	2.00%	1.91%	1.96%
3	11.6%	10.1%	9.30%	8.50%	5.30%	5.10%	4.93%	5.01%
4	18.5%	16.1%	14.8%	13.7%	8.70%	8.40%	8.24%	8.31%
5	24.3%	21.1%	19.5%	18.2%	11.6%	11.2%	11.1%	11.3%
6	29.2%	25.6%	23.6%	22.3%	14.5%	13.9%	13.8%	14.0%
7	40.0%	35.2%	32.9%	31.0%	20.9%	19.9%	20.1%	20.4%
8	48.4%	43.6%	41.0%	38.7%	26.9%	25.6%	25.9%	26.2%
9	53.7%	48.7%	46.0%	43.6%	31.0%	29.4%	29.8%	30.3%
10	59.0%	53.8%	51.0%	48.5%	35.2%	33.4%	33.9%	34.6%

eGFR, estimated glomerular filtration rate; TKV, total kidney volume.