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. 2017 Sep 21;18(10):806–815. doi: 10.1080/15384047.2017.1373219

Figure 2.

Figure 2.

Down-regulation of KLF5 expression in CAFs inhibits the growth, migration and invasion of gastric cancer cells. (A, B) Cell growth ability was measured using MTT and clonogenic assay. The growth ability of gastric cells cultured with CAFs transfected lentivirus-KLF5 was significantly higher than the corresponding control, but the growth ability of gastric cancer cultured with CAFs transfected lentivirus-siRNA-KLF5 was significantly slower than the corresponding control. (C-D) Cell migration ability was measured by Transwell migration assay. The migration ability of gastric cells cultured with CAFs transfected lentivirus-KLF5 and lentivirus-siRNA-KLF5 was significantly greater and weaker than the corresponding control, respectively. (E, F) Cell invasion ability was measured by Transwell invasion assay. The invasion ability of gastric cells cultured with CAFs transfected lentivirus-KLF5 and lentivirus-siRNA-KLF5 was significantly greater and weaker than the corresponding control, respectively. Data represent mean ± SEM from three independent experiments; *P < 0.05 by t test, **P < 0.01 by t test.