Supplementary Figure 1.
(A) Optimization of the LASSO tuning parameter regarding the criterion of cross-validated log likelihood in step 2 of the score building procedure. (B) Results of multivariable L1 penalized (LASSO) Cox regression with time-to-event variable EFS (step 2 of the score building procedure). The fitted regression coefficients are shown in dependence of the LASSO tuning parameter. Variables not shrunk to zero at the optimal tuning parameter λopt are highlighted in colors and were included in the next step of score building. (C) EFS and OS of patients of the training set (n = 411) stratified according to the NB-Risk Score. LR, low risk; IR, intermediate risk; HR, high risk. (D) Multivariable Cox regression analysis of risk groups defined by the German NB2004 trial and the NB-Risk Score for EFS in patients of the training set. OG, observation group; MRG, intermediate-risk group; HRG, high-risk group according to NB2004 stratification and LR, low risk; IR, intermediate-risk; HR, high risk according to NB-Risk Score stratification.