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. 2017 Nov 7;17:150. doi: 10.1186/s12871-017-0438-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Western blotting of Nav1.7 using the total protein from ipsilateral L4-L6 DRGs of SMIR surgery rats, statistical summaries of western blot analysis: The expression of Nav1.7 protein was increased on days 10,15 and 20 after SMIR surgery (*P < 0.05,**P < 0.01, ***P < 0.001 vs naive group; n = 3). b-c Effect of pretreatment with i.t injection of ProTx-II (once daily from 1d before surgery until 7d after surgery) on the mechanical hyperalgesia induced by SMIR model rats. The result showed that selective Nav1.7 channel blocker can significantly reduced hyperalgesia induced by SMIR in a dose dependent way (*P < 0.05, ***P < 0.001 vs SMIR group; n = 6)