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. 2017 Nov 7;17:150. doi: 10.1186/s12871-017-0438-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a-b Effects of pretreatment with i.t injection of PDTC (once daily from 1d before surgery until 10d after surgery) on the mechanical hyperalgesia induced by SMIR model (**P < 0.01,***P < 0.001,n = 6). c-d Western blotting result of nucleoprotein p-p65 from ipsilateral L4-L6 DRGs of SMIR surgery rats. Statistical summaries of western blot analysis: The expression of p-p65 protein was increased at 10d (n = 4) and 15d (n = 5) after SMIR surgery compared with incision groups, whereas pretreatment with PDTC (once daily from 1d before surgery until 7d after surgery) can prevent the activation of NF-κB at 10d (n = 4) and 15d (n = 5) compared with SMIR group (*P < 0.05 vs incision group; #P < 0.05 vs SMIR group)