Table 4.

Crude incidence rates and adjusted hazard ratios for recurrent fatal or nonfatal stroke or coronary heart disease according to CKD and hypertension control status

Baseline characteristics	Number	Person-years	Events	Crude IR [95% CI] (per 1000 person-years)	Adjusted HR [95% CI]a	P for interactionb
Stroke or coronary heart diseasec						0.10
All participants	898	5373	204	38.0 [33.0–43.5]
Without CKD
cHT	245	1554	50	32.2 [24.2–42.1]	1
ucHT	404	2492	94	37.7 [30.7–45.9]	1.08 [0.76–1.53]
aTRH	59	381	8	21.0 [9.9–39.6]	0.60 [0.28–1.29]
With CKD
cHT	66	352	13	36.9 [20.7–61.3]	1.10 [0.59–2.06]
ucHT	89	434	25	57.6 [38.2–83.6]	1.70 [1.04–2.80]
aTRH	35	159	14	87.8 [50.3–143.3]	2.15 [1.16–3.98]
Stroke
All participants	235	1381	32	23.2 [16.1–32.3]
Without CKD
cHT	59	377	6	15.9 [6.6–32.8]	1
ucHT	106	636	16	25.2 [15.0–39.9]	Not estimated
aTRH	14	90	1	11.1 [1.0–51.8]	Not estimated
With CKD
cHT	10	49	0	Not estimated	Not estimated
ucHT	34	165	7	42.3 [18.9–83.1]	Not estimated
aTRH	12	64	2	31.0 [6.2–99.4]	Not estimated
Coronary heart disease						0.13
All participants	714	4379	143	32.7 [27.6–38.3]
Without CKD
cHT	198	1270	38	29.9 [21.5–40.6]	1
ucHT	322	2063	64	31 [24.1–39.3]	1.00 [0.66–1.52]
aTRH	48	310	4	12.9 [4.3–30.7]	0.40 [0.14–1.15]
With CKD
cHT	59	322	12	37.3 [20.4–63.1]	1.25 [0.64–2.43]
ucHT	61	299	16	53.4 [31.8–84.7]	1.98 [1.08–3.64]
aTRH	26	114	9	78.5 [38.8–143.2]	2.04 [0.95–4.37]

aTRH, apparent treatment-resistant hypertension (defined as systolic and/or diastolic blood pressure ≥140 and/or ≥90 while taking ≥3 antihypertensive drugs or number of antihypertensive drugs ≥4); cHT, controlled hypertension (defined as systolic and diastolic blood pressure <140/90 mm Hg while taking 1−3 antihypertensive drugs); CKD, chronic kidney disease (defined as estimated glomerular filtration rate <60 mL/min/1.73m²); HR, hazard ratio; IR, incidence rate; ucHT, uncontrolled hypertension (systolic and/or diastolic blood pressure ≥140 and /or ≥90 while taking 1 or 2 antihypertensive drugs).

^cCombined fatal and nonfatal stroke and CHD: defined as the recurrence of either a stroke or CHD.

^aAll models were adjusted for center, sex, diabetes, body mass index, hypercholesterolemia, smoking status, and education level.

^bAll interactions between hypertension control status and chronic kidney disease.

^cCombined fatal and nonfatal stroke and CHD: defined as the recurrence of either a stroke or CHD.