Figure 3.
Summary of the integrated roles of the kidney, extrarenal mechanisms, and gastrointestinal effectors in modulating potassium homeostasis. It demonstrates that the undamped increase in plasma K+ in response to potassium administration is progressively attenuated by the adaptive responses by the kidney, by a hierarchy of nonrenal mechanisms including participation by insulin and glucose, and by gastrointestinal mechanisms evoked by gastrointestinal potassium sensors.33 Courtesy of Murray Epstein.
Adapted with permission from Youn JH. Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May;33:248–256. Copyright © 2013, Elsevier Inc.