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. 2017 Nov 8;12(11):e0187206. doi: 10.1371/journal.pone.0187206

Table 1. List of the 25 NB pediatric patients analyzed.

TUMOR
NUMBER		 CLUSTER SEX AGE AT DIAGNOSIS (months) STAGE (INSS) ONSET SITE OUTCOME1 DNA PLOIDY2 HISTOLOGY3 N-myc4 HIF-1α5 PDK15 PHD35
1 Hypoxic male 16 4 Abdomen-adrenal gland Relapsed 1 UH - 71–100% 71–100% 1–20%
2 Hypoxic male 17 4 Thorax-abdomen Deceased 2.03 UH + 71–100% 71–100% 1–20%
3 Hypoxic male 43 4 Abdomen-adrenal gland Deceased 1 UH + 71–100% 71–100% 1–20%
4 Hypoxic male 55 4 Abdomen-adrenal gland Deceased 1 UH - 71–100% 51–70% 1–20%
5 Hypoxic male 9 4S Abdomen-retroperitoneal ganglia Resid. disease 1 FH + 71–100% 71–100% 1–20%
6 Hypoxic female 21 3 Abdomen Deceased na UH + 71–100% 51–70% <1%
7 Hypoxic male 40 3 Abdomen-adrenal gland Relapsed 2.01 UH - 51–70% 21–50% <1%
8 Hypoxic female 69 1 Abdomen Cont. remiss. na FH + 71–100% 51–70% 1–20%
9 Normoxic male 0.71 4 Abdomen-retroperitoneal ganglia Resid. disease na FH + 1–20% 1–20% 1–20%
10 Normoxic male 7 4S Abdomen-retroperitoneal ganglia Resid. disease 1.74 FH - 1–20% 1–20% 51–70%
11 Normoxic male 5 3 Abdomen-pancreas Cont. remiss. 1.57 FH - 1–20% <1% 71–100%
12 Normoxic male 6 3 Thorax Cont. remiss. 1.27 FH - 1–20% <1% 71–100%
13 Normoxic female 11 3 Thorax Resid. disease 1.31 FH - 1–20% 21–50% 51–70%
14 Normoxic male 146 3 Pelvis Deceased 1.97 UH + 1–20% 1–20% 51–70%
15 Normoxic female 7 2B Thorax Cont. remiss. na FH - <1% 1–20% 71–100%
16 Normoxic male 10 2B Abdomen Resid. disease 1.63 FH - 1–20% <1% 21–50%
17 Normoxic female 10 2B Pelvis Cont. remiss. 1.46 FH - <1% 1–20% 71–100%
18 Normoxic male 0.5 2A Abdomen Cont. remiss. 1.64 FH - 1–20% 1–20% 71–100%
19 Normoxic male 4 2A Abdomen Cont. remiss. 1.53 FH - 1–20% 1–20% 71–100%
20 Normoxic female 2 1 Abdomen-adrenal gland Cont. remiss. 1.73 FH - <1% 1–20% 51–70%
21 Normoxic male 3 1 Abdomen-adrenal gland Cont. remiss. 1.34 FH - 1–20% 1–20% 51–70%
22 Normoxic male 3 1 Abdomen-adrenal gland Cont. remiss. 1.75 FH - 1–20% <1% 71–100%
23 Normoxic male 7 1 Abdomen-adrenal gland Cont. remiss. na FH - 21–50% 1–20% 71–100%
24 Normoxic female 24 1 Thorax-abdomen Resid. disease 1.66 FH - 21–50% 21–50% 71–100%
25 Normoxic female 53 1 Abdomen-retroperitoneal ganglia Cont. remiss. 1.26 FH - 51–70% 1–20% 71–100%

Clinicopathological characteristics of patients and tumor samples examined.

1 Outcome: Relapsed = relapsed NB after chemotherapy; Resid. Disease = residual NB after chemotherapy; Cont. remiss. = NB in continuous remission.

2 DNA ploidy is displayed as index of DNA content: 1 = diploidy; >1 = hyperdiploidy; <1 = hypodiploidy; na = not available.

3 Histology: UH = unfavorable FH = favorable.

4 N-myc amplification status: + = amplified; - = normal.

5 The protein expression level of HIF-1α, PDK1 and PHD3, obtained by immunohistochemical staining, is expressed as percentage of positive cells: <1% or 1–20% = low positivity; 21–50% = medium positivity; 51–70% or 71–100% = high positivity.